SR59230A

SKU: orb1220265

Description

MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.

Key Properties

• CAS Number: 174689-39-5
• MW: 415.48
• Purity: >98% (HPLC)
• Formula: C??H??NO?
• SMILES: O[C@@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.O=C(O)C(O)=O
• Target: Adrenergic Receptor
• Solubility: DMSO : 31.25 mg/mL (75.21 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA. Animal model: Male C-57BL6J wild-type mice (22-35 g). Dosage: 0.5 or 5 mg/kg. Administration: Injected s. c. ; administered 30 min prior to the injection s. c. of MDMA (20 mg/kg). Result: Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.
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• In Vitro:
  SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines. Cell Viability Assay Cell line: Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C). Concentration: 100 nM, 1 μM, 5 μM, 10 μM, and 50 μM. Incubation time: 24 hours. Result: Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1 μM for Neuro-2A cells and 5 μM for SK-N-BE(2) and BE(2)C).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Adrenergic Receptor