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SOD (EC) Antibody: HRP

Catalog Number: orb147621

DispatchUsually dispatched within 2-3 weeks
$ 570.00
Catalog Numberorb147621
CategoryAntibodies
DescriptionMouse monoclonal to SOD (HRP). Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms. There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space. SOD3 can also be distinguished by its heparin-binding capacity..
Species/HostMouse
ClonalityMonoclonal
Clone Number4GG11G6
Tested applicationsELISA, IHC, WB
ReactivityGuinea pig, Human, Mouse, Rat
IsotypeIgG1 Kappa
ImmunogenHuman extracellular SOD purified from aortas
Concentration1 mg/ml
Dilution rangeWB (1:1000), IHC (1:100), ICC/IF (1:100)
ConjugationHRP
MW35kDa
TargetSOD3
Entrez6649
UniProt IDP08294
NCBINP_003093.2
StorageConjugated antibodies should be stored according to the product label
Buffer/Preservatives73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Alternative namesEC SOD antibody, EC-SOD antibody, Extracellular su
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NoteFor research use only
Application notes1 µg/ml of SMC-167 was sufficient for detection of EC-SOD in 20 µg of human cartilage lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Expiration Date12 months from date of receipt.
SOD (EC) Antibody: HRP

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SOD3 Monoclonal Antibody, Clone 4GG11G6. Tissue: cartilage. Species: Human. Primary Antibody: Mouse Anti-SOD3 Monoclonal Antibody at 1:1000. Left: control, middle: young cartilage, right: cartilage with osteoarthritis.

SOD (EC) Antibody: HRP

Western Blot analysis of Human cartilage lysates showing detection of SOD3 protein using Mouse Anti-SOD3 Monoclonal Antibody, Clone 4GG11G6. Primary Antibody: Mouse Anti-SOD3 Monoclonal Antibody at 1:1000. Left: Control, Middle: Young cartilage, Right: Cartilage sample with osteoarthritis-arthritis.

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