SNAP 94847

SKU: orb1689891

Description

SNAP 94847

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 487051-12-7
• MW: 478.57
• Formula: C₂₉H₃₂F₂N₂O₂
• SMILES: CC=1C(=CC(NC(C(C)C)=O)=CC1)C2CCN(CC3=CC=C(OC4=CC(F)=C(F)C=C4)C=C3)CC2
• Target: Melanin-concentrating Hormone Receptor (MCHR),GPCR
• Solubility: DMSO:20 mg/mL (41.79 mM)

Bioactivity

• Target IC50:
  MCH1R:2.2 nM (Ki, cell free)
• In Vivo:
  SNAP-94847 (10 mg/kg, p.o.) had no effect on basal water consumption measured over 2 h: vehicle-treated (2.0 mL); 16g-treated (2.3 mL). MCH-evoked water intake was inhibited significantly by SNAP-94847 at doses of 1.0, 2.5, and 10 mg/kg . BALB/c mice treated for 21 days with fluoxetine or SNAP 94847 (20 mg/kg/day) showed marked increases in quinpirole-induced locomotor activity, with the onset of hyper-locomotion appearing earlier in the time course after SNAP 94847 compared to fluoxetine. Administration of either compound for 7 days was also sufficient to augment the quinpirole response in BALB/c mice . The intra-locus coeruleus and intracerebroventricular injections of melanin-concentrating hormone and chronic injections of corticosterone increased immobility time in the forced swim test and decreased sucrose preference in the sucrose preference test. All these depressive-like behaviors were reversed by an intra-locus coeruleus microinjection of SNAP-94847 .
• In Vitro:
  SNAP-94847 showed a favorable combination of MCH1 receptor affinity (Ki: 2.2 nM) and human R1A receptor (>80-fold) and D2 (>500-fold) selectivity .
• Animal Research:
  Chronically treated Sprague–Dawley rats were administered fluoxetine (18 mg/kg/day) or SNAP 94847 (20 mg/kg/day) via oral gavage in 20% beta-cyclodextrin for 2 weeks (1 injection, 6 h into light cycle). For acute treatment, drugs were given orally in 20% betacyclodextrin 1 h before testing. On each test day, locomotor activity was recorded during a 60 min habituation to the novel locomotor cage, after which the rats were administered quinpirole (0.3 mg/kg, i.p.) and returned immediately to the cage, where locomotor activity was measured for an additional 180 min. In each case-control animals were administered the corresponding vehicle, without drug .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antidepressant, anxiolytic, anxiety, inhibit, Inhibitor, MelaninconcentratingHormoneReceptor(MCHR), Melanin-concentrating Hormone Receptor, Melaninconcentrating Hormone Receptor (MCHR), MelaninconcentratingHormoneReceptor, Melanin concentrating hormone receptor 1, MCHR, MCH1-R, MCHR1 (GPR24), SNAP94847, SNAP-94847, SNAP 94847

Compound Identifiers

PubChem CID

16756754