SNAP-94847

SKU: orb1221004

Description

SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.

Key Properties

• CAS Number: 487051-12-7
• MW: 478.57
• Purity: >98% (HPLC)
• Formula: C₂₉H₃₂F₂N₂O₂
• SMILES: Cl.CC(C)C(=O)Nc1ccc(C)c(c1)C1CCN(Cc2ccc(Oc3ccc(F)c(F)c3)cc2)CC1
• Target: MCHR
• Solubility: DMSO: 20 mg/mL (41.79 mM)

Bioactivity

• In Vivo:
  SNAP 94847 (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2, 19) = 11.31, treatment × time: F(34, 323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals. SNAP 94847 (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3, 28) = 8.971; treatment × time: F(51, 476) = 11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group, this effect is significant over 180 min. SNAP 94847 (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study. Animal model: Rat. Dosage: 20 mg/kg. Administration: Oral administration; 20 mg/kg; 14 days. Result: Exhibited a exaggerated locomotor response to acute quinpirole. Animal model: Rat (PK study). Dosage: 10 mg/kg. Administration: oral gavage; 10 mg/kg. Result: Exhibited good physicochemical properties in rats.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MCHR