SIRT5 inhibitor 1

SKU: orb1708520

Description

SIRT5 inhibitor 1 is a potent and selective small molecule targeting human SIRT5 deacylase with an IC50 of 0.11 µM. It serves as a valuable chemical probe for investigating SIRT5's role in metabolic regulation, cancer, and ageing-related pathologies in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2166487-21-2
• MW: 674.81
• Purity: 98.50% (May vary between batches)
• Formula: C₃₁H₃₉FN₆O₆S₂
• SMILES: OC(=O)CCNC(=S)NCCCC[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCC1
• Target: Sirtuin
• Solubility: DMSO:50 mg/mL (74.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.96 mM)

Bioactivity

• Target IC50:
  Sirtuin:0.11 μM |Sirtuin:0.11 μM
• In Vitro:
  SIRT5 inhibitor 1 is a very potent inhibitor of human sirtuin 5 deacylase(IC50 of 0.11 μM, >100-fold from compound.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sirtuin, SIRT5 inhibitor 1, SIRT-5 inhibitor 1

Compound Identifiers

PubChem CID

134828254