SIRT5 inhibitor 4

SKU: orb1688578

Description

Compound 11 (SIRT5 inhibitor 4) is a selective, dose-dependent inhibitor of SIRT5 with an IC50 of 26.4 µM, showing no activity against SIRT1-3 at 400 µM. It is a valuable chemical probe for investigating SIRT5's role in cancer metabolism and tumorigenesis in cellular and biochemical studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 708992-34-1
• MW: 369.39
• Purity: 99.97%
• Formula: C₁₈H₁₅N₃O₄S
• SMILES: O=C(O)C1=CC=C(C=C1O)NC2=NC(=CS2)C=3C=CC(=CC3)NC(=O)C
• Target: Sirtuin

Bioactivity

• Target IC50:
  SIRT5:26.4 μM
• In Vitro:
  SIRT5 inhibitor 4 was identified as a selective SIRT5 inhibitor (IC₅₀ = 26.4 ± 0.8 μM) with no inhibition on SIRT1–3.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

1092447