Simufilam dihydrochloride

SKU: orb1298310

Description

Simufilam dihydrochloride is an orally bioavailable small molecule that selectively binds to misfolded filamin A (FLNA) in Alzheimer's disease research. It restores FLNA's normal function, which has been shown in experimental models to improve synaptic signaling and reduce neuroinflammation by disrupting pathological protein interactions.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2480226-06-8
• MW: 332.3
• Purity: 99.72% (May vary between batches)
• Formula: C₁₅H₂₃Cl₂N₃O
• SMILES: [H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
• Target: Beta Amyloid,Others,Microtubule Associated,iGluR,mTOR,AChR
• Solubility: DMSO:65 mg/mL (195.61 mM)

Bioactivity

• In Vivo:
  Simufilam dihydrochloride (22 mg/kg; p.o.) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam dihydrochloride significantly improves spatial memory.
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• In Vitro:
  Simufilam dihydrochloride (1 pM~1 nM) increases NMDA/glycine-induced Arc expression in a dose-dependent manner. Simufilam dihydrochloride (1 nM, 1 hour) largely restores filamin A to its native conformation and effectively normalizes receptor activities in AD frontal cortices. Simufilam dihydrochloride dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam dihydrochloride reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

a7nAChR, inhibit, Inhibitor, PTI125, PTI-125, PTI125 Dihydrochloride, PTI-125 Dihydrochloride, PTI-125 dihydrochloride, PTI 125, PTI 125 Dihydrochloride, Simufilam, Simufilam dihydrochloride, Simufilam Dihydrochloride

Compound Identifiers

PubChem CID

155068887