Simufilam dihydrochloride

SKU: orb1218289

Description

Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.

Images & Validation

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Key Properties

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CAS Number	2480226-06-8
MW	332.3
Purity	>98% (HPLC)
Formula	C₁₅H₂₃Cl₂N₃O
SMILES	[H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
Target	filamin A (FLNA)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PTI-125 dihydrochloride

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Quick Database Links

Gene Symbol

filamin A (FLNA)

Protocol Information

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Purity:	99.72% (May vary between batches)
CAS Number:	2480226-06-8
MW:	332.3
Formula:	C₁₅H₂₃Cl₂N₃O