Silymarin

SKU: orb1300571

Description

Silymarin (Silybin B) is a flavonoid compound isolated from milk thistle ( Silybum marianum ). It is widely used in research for investigating hepatoprotective mechanisms, with applications in both in vitro cell-based assays and in vivo models of liver injury.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 65666-07-1
• MW: 482.44
• Formula: C₂₅H₂₂O₁₀
• SMILES: COc1cc(ccc1O)C1Oc2ccc(cc2OC1CO)C1Oc2cc(O)cc(O)c2C(=O)C1O
• Target: SARS-CoV
• Solubility: 50% PEG300+50% saline:20 mg/mL (41.46 mM);Ethanol:1 mg/mL (2.07 mM);DMSO:71 mg/mL (147.17 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.18 mM)

Bioactivity

• In Vivo:
  The intravenous injection LD50 of Silymarin is 391.4 mg/kg, 70.1 mg/kg, 142.3 mg/kg for mice, rats, rabbits, respectively
• In Vitro:
  Mechanism of Silymarin involves different biochemical reactions, such as stimulation o the rate of ribosomal RNA synthesis by stimulatin the transcription of polymerase I and ribosomal RNA genes, blockage of alpha-glycoside loops toxin intake, and protection of cell membranes from free radical-induced damage. Silymarin also displays a substantial Protective effect against UVB-induced canceration at different stages, possibly through its strong antioxidant properties.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

thistle, Silybin B, Silymarin, SARS-CoV, SARSCoV, SARS coronavirus, resistance, proliferation, carcinoma, chemopreventive, angiogenesis, Milk, Inhibitor, inhibit, insulin, HCC, hepatocellular

Compound Identifiers

PubChem CID

3085830