Serotonin

SKU: orb1297148

Description

Serotonin (5-HT) is an endogenous monoamine neurotransmitter and 5-HT receptor agonist that modulates central nervous, digestive, and cardiovascular functions. It is widely used in neuroscience, pharmacology, and physiology research for in vitro receptor studies and in vivo investigations of mood, cognition, and gut-brain axis signaling.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-67-9
• MW: 176.22
• Purity: 95.94% (May vary between batches)
• Formula: C₁₀H₁₂N₂O
• SMILES: NCCc1c[nH]c2ccc(O)cc12
• Target: Endogenous Metabolite,5-HT Receptor,Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (18.73 mM);DMSO:255 mg/mL (1447.05 mM)

Bioactivity

• Target IC50:
  5-HT1A:117 nM (EC50)
• In Vivo:
  METHODS: To study the pain hypersensitivity of Serotonin, Serotonin (10 uM; 20 μl was intradermal injected into mice, and the mice were tested at 15, 30, 45, 60, 90, 120, 180 and 240 minutes. RESULTS: Compared with the control group receiving saline treatment, Serotonin produced a strong hypersensitivity reaction (p<0.001). METHODS: To study the role of IL-13-mediated 5-HT signaling in the pathogenesis of colitis, Serotonin (100 mg/kg) was subcutaneously injected into male IL-13-deficient mice 3 days before induction of DSS colitis, twice a day for 8 consecutive days. RESULTS: After inducing DSS colitis, the content of 5-HT in the colon of IL-13-/- mice that received Serotonin increased significantly.
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• In Vitro:
  METHODS: Mouse B16 melanoma cells were treated with Serotonin for 2 days to detect the anti-melanin production activity. RESULTS: Serotonin is slightly active or inactive in the inhibitory medium dimming, with IC50> 30 μM.
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Storage & Handling

• Storage: store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, EndogenousMetabolite, Endogenous Metabolite, COMT, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-hydroxytryptamine, 5-HT, 5-HT Receptor, 5HT Receptor, Serotonin Receptor, Serotonin

Compound Identifiers

PubChem CID

5202