Scopoletin

SKU: orb1304772

Description

Scopoletin, also known as Esculetin 6-methyl ether, is a natural coumarin isolated from Scopolia carniolica. It functions as an acetylcholinesterase (AChE) inhibitor and is utilized in neurological research, including in vitro enzyme assays and studies of plant physiology.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 92-61-5
• MW: 192.17
• Purity: 99.88% (May vary between batches)
• Formula: C₁₀H₈O₄
• SMILES: COc1cc2ccc(=O)oc2cc1O
• Target: AChR,Cholinesterase (ChE),Apoptosis
• Solubility: DMSO:62.5 mg/mL (325.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.41 mM)

Bioactivity

• In Vivo:
  Female BALB/c mice were treated with Mogroside V (2.5, 5 and 10 mg/kg) for 1 h prior to intranasal injection of LPS (10 μg in 50 μl). After 12 h, airway inflammation in the ALI model was determined by the wet/dry weight (W/D) ratio, myeloperoxidase (MPO) activity of lung tissue, leukocyte recruitment and cytokine levels in the bronchoalveolar lavage fluid (BALF). Additionally, lung tissue was examined by histology and western blotting to investigate the changes in pathology and the signalling in the presence and absence of Mogroside V. Mogroside V at 5 and 10 mg/kg inhibited airway inflammation induced by LPS as measured by the decrease in the histological changes (44 and 67.3% reduction in lung injury score, respectively), a 28.9 and 55.3% reduction in lung MPO activity, and inflammatory cell counts, interleukin-1β (IL-1β, 382 and 280 pg/ml, respectively), IL-6 (378 and 232 pg/ml, respectively) and tumor necrosis factor-α (TNF-α, 12.5 and 7.8 ng/ml, respectively) levels in the BALF. Additionally, Mogroside V treatment reduced the activation of cyclooxygenase 2 (COX-2), inducible NO synthase (iNOS), and the nuclear factor (NF)-κB.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Scopoletin, Gelseminic acid, Esculetin 6-methyl ether, Inhibitor, inhibit, mAChR, Apoptosis, 6-Methylesculetin, AChE, Chrysatropic acid, Cholinesterase (ChE)

Compound Identifiers

PubChem CID

5280460