S100A9 Antibody / MRP14 / Calgranulin B / Calprotectin L1H

• Catalog Number: orb750149
• Category: Antibodies
• Description: S100A9, also known as Calgranulin B or MRP14 (and Calprotectin L1H), is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. [UniProt]
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: PS1A9-1
• Tested applications: IHC-P
• Reactivity: Human
• Isotype: Mouse IgM, kappa
• Immunogen: Recombinant human protein was used as the immunogen for the S100A9 antibody.
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT (1)
• Purity: PEG precipitation
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Hazard Information: This S100A9 antibody is available for research use only.
• UniProt ID: P06702
• Storage: Store the S100A9 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
• Buffer/Preservatives: 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
• Note: For research use only
• Application notes: Titering of the S100A9 antibody may be required for optimal performance.1. Not suitable for frozen tissue testing.
• Expiration Date: 12 months from date of receipt.