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Rigosertib

SKU: orb1217844

Description

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.

Images & Validation

Key Properties

CAS Number592542-59-1
MW451.49
Purity>98% (HPLC)
FormulaC21H25NO8S
SMILESCOC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
TargetApoptosis
SolubilityDMSO:75 mg/mL (166.12 mM; Need ultrasonic)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ON-01910

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Rigosertib (orb1217844)

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100 mg
200 mg
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2 mg
$ 80.00
5 mg
$ 100.00
10 mg
$ 160.00