Rigosertib sodium (b)

SKU: orb1226749

Description

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.

Key Properties

• CAS Number: 1225497-78-8
• MW: 473.47
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₄NNaO₈S
• SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
• Target: PLK
• Solubility: Water: 95 mg/mL (200.64 mM); DMSO: 95 mg/mL (200.64 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ON-01910

Quick Database Links

Gene Symbol

PLK