Rigosertib sodium

SKU: orb1301462

Description

Rigosertib sodium

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 592542-60-4
• MW: 473.47
• Purity: 98.00%
• Formula: C₂₁H₂₄NNaO₈S
• SMILES: COc1c(cc(cc1)CS(=O)(=O)/C=C/c1c(cc(cc1OC)OC)OC)NCC(=O)[O-].[Na+]
• Target: PI3K,Apoptosis,PLK
• Solubility: H2O:87 mg/mL (183.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.56 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:88 mg/mL (185.86 mM)

Bioactivity

• Target IC50:
  Fyn:182 nM (IC50)|PDGFR:18 nM (IC50)|CDK1:260 nM (IC50)|FLK1:42 nM (IC50)|PLK2:260 nM (IC50)|PLK1:9 nM (IC50)|BCR-ABL:32 nM (IC50)|Src:155 nM (IC50)
• Cell Research:
  Cells are grown in either DMEM or RPMI supplemented with 10% fetal bovine serum and 1 unit/mL penicillin-streptomycin solution. Tumor cells are plated into six-well dishes at a density of 1 × 105cells/mL/well, and Rigosertib is added 24 hours later at various concentrations. Cell counts are determined from duplicate wells after 96-hour of treatment. The total number of viable cells is determined by trypan blue exclusio(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Inhibitor, Estybon, ON 01910, ON01910, ON-01910, PLK1, PLK, inhibit, PI3K, Phosphoinositide 3-kinase, Polo-like Kinase (PLK), Rigosertib, Rigosertib sodium

Compound Identifiers

PubChem CID

23696523