RB1 (M) Antibody, Rabbit Polyclonal

SKU: orb66933

Description

Rabbit polyclonal to RB1.Retinoblastoma-associated protein b) is a tumor suppressor and a key regulator of entry into celldivision. RB1 acts as a transcription repressor of E2F1 target genes. The hypophosphorylated, activeform of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest.RB1 is directly involved in heterochromatin formation by maintaining overall chromatin structure and,in particular, that of constitutive heterochromatin by stabilizing histone methylation. When it is time fora cell to enter S phase, complexes of cyclin-dependent kinases (CDK) and cyclins phosphorylate RB1and inhibit its activity.

Research Area

Epigenetics & Chromatin

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: middle region of human RB1
• Molecular Weight: 106
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-RB1 antibody,anti-Retinoblastomaassociated protein antibody,anti-p105Rb antibody,anti-pRb antibody,anti-pp110 antibody,anti-Rb antibody

Quick Database Links

UniProt

P06400