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PROTAC PARP1 degrader

SKU: orb1989660

Description

This small molecule PROTAC induces targeted degradation of PARP1. It demonstrates in vitro activity with an IC50 of 6.12 µM in MDA-MB-231 breast cancer cells after 24-hour treatment. Such degraders are valuable research tools for studying PARP1 biology and exploring novel therapeutic strategies in oncology.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2369022-68-2
MW1145.1
FormulaC58H63Cl2N11O10
SMILESC(=O)(N1[C@]([C@](N=C1C2=C(OC(C)C)C=C(OC)C=C2)(C3=CC=C(Cl)C=C3)[H])(C4=CC=C(Cl)C=C4)[H])N5CC(=O)N(CC(NCCOCCOCCOCCOCCN6C=C(N=N6)C7=CC=C(C=C7)N8N=C9C(=C8)C=CC=C9C(N)=O)=O)CC5
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information