PROTAC PARP1 degrader

SKU: orb1989660

Description

This small molecule PROTAC induces targeted degradation of PARP1. It demonstrates in vitro activity with an IC50 of 6.12 µM in MDA-MB-231 breast cancer cells after 24-hour treatment. Such degraders are valuable research tools for studying PARP1 biology and exploring novel therapeutic strategies in oncology.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2369022-68-2
• MW: 1145.1
• Formula: C₅₈H₆₃Cl₂N₁₁O₁₀
• SMILES: C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)N5CC(=O)N(CC(NCCOCCOCCOCCOCCN6C=C(N=N6)C7=CC=C(C=C7)N8N=C9C(=C8)C=CC=C9C(N)=O)=O)CC5
• Target: PROTACs,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138454769