PROTAC PARP1 degrader-4

SKU: orb2945302

Description

PROTAC PARP1 degrader-4 (Compound 180055) is a selective degrader with DC50 values of 180-240 nM in breast cancer cell lines. It induces PARP1 ubiquitination and degradation, inhibiting its enzymatic activity without significant DNA trapping. This compound is a valuable research tool for studying PARP1-dependent processes and BRCA-mutant cancers in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• MW: 920.145
• Formula: C₅₁H₆₂FN₇O₆S
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCC(=O)N(C)CC4=CC=C(C=C4)C5=C6CCNC(=O)C7=C6C(=CC(=C7)F)N5)O
• Target: PARP,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677054