PROTAC EGFR degrader 9

SKU: orb3134321

Description

PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.

Research Area

Cell Biology

Key Properties

• CAS Number: 2992670-33-2
• MW: 899.98
• Formula: C₄₅H₄₈F₃N₉O₆S
• SMILES: O=C1C=2C=CC=C(NC(=O)CCCCCCN3CCN(C4=CC=C(C=C4)NC=5N=CC(=C(N5)C6=CN(C=7C=CC=CC67)S(=O)(=O)CC)C(F)(F)F)CC3)C2CN1C8C(=O)NC(=O)CC8
• Target: PROTACs,Apoptosis,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,Apoptosis,EGFR