MS9449

SKU: orb1982767

Description

MS9449 is a potent PROTAC degrader of wild-type and L858R mutant EGFR, with Kd values of 17 nM and 10 nM, respectively. It induces degradation via both the proteasome and autophagy pathways, demonstrating robust anti-proliferative activity in NSCLC cell models, which supports its utility in targeted cancer therapy research.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2772612-96-9
• MW: 1151.82
• Formula: C₆₀H₇₆ClFN₁₀O₈S
• SMILES: N(C=1C2=C(C=C(OC)C(OCCCN3CCN(C(CCCCCCCCCCNC(C[C@H](NC(=O)[C@H]4N(C([C@H]([C@H](C)C)C=5ON=C(C)C5)=O)C[C@H](O)C4)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)=O)CC3)=C2)N=CN1)C8=CC(Cl)=C(F)C=C8
• Target: EGFR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164517155