PROTAC EGFR degrader 8

SKU: orb2278163

Description

PROTAC EGFR degrader 8 (T-184) is a potent and selective degrader of EGFR, demonstrating a DC50 of 15.56 nM in HCC827 cells and anti-proliferative activity in NSCLC lines like H1975 and PC-9. It serves as a valuable chemical tool for investigating targeted protein degradation in non-small cell lung cancer research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2925923-46-0
• MW: 796.32
• Formula: C₄₀H₄₆ClN₁₁O₅
• SMILES: O(C)C=1C=C(C=CC1NC=2N=C(NC3=C(C(NC)=O)C=CC=C3)C(Cl)=CN2)N4CCN(C(CN5CCN(CC5)C6=CC=C(NC7C(=O)NC(=O)CC7)C=C6)=O)CC4
• Target: PROTACs,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168476135