PROTAC CDK9 Degrader-1

SKU: orb1689887

Description

PROTAC CDK9 Degrader-1 is a heterobifunctional molecule designed to selectively degrade CDK9 by linking a cereblon E3 ligase ligand to a CDK9-binding moiety. This tool compound enables the study of CDK9's role in transcription and oncology, with applications in both cellular and in vivo models for cancer and inflammatory disease research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2118356-96-8
• MW: 613.66
• Purity: 95.10% (May vary between batches)
• Formula: C₃₃H₃₅N₅O₇
• SMILES: O=C(NC1=NNC(=C1)C2CCC2)CC3=CC=C(OCCCCCOC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)C=C3
• Target: PROTACs,CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.38 mM);DMSO:80 mg/mL (130.37 mM)

Bioactivity

• In Vitro:
  In HCT116 cells, PROTAC CDK9 Degrader-1 (Compound 3) (2.5-20 μM; 6 h) induced CDK9 degradation in a dose-dependent manner.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK, CDK9, Cyclin dependent kinase, PROTAC CDK9 Degrader-1, PROTAC CDK9 Degrader 1, PROTAC CDK9 Degrader1, PROTAC CDK-9 Degrader-1, PROTACs

Compound Identifiers

PubChem CID

132472236