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PKC-theta inhibitor

SKU: orb1689889

Description

This small molecule is a potent and selective inhibitor of protein kinase C theta (PKC-θ), exhibiting an IC50 of 12 nM. It is a valuable research tool for studying T-cell activation and immune signaling pathways in both cellular and animal models of inflammation and autoimmunity.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number736048-65-0
MW454.45
Purity99.46% (May vary between batches)
FormulaC20H25F3N6O3
SMILESNCC1CCC(CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+]([O-])=O)CC1
TargetPKC
SolubilityDMSO:62.5 mg/mL (137.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.4 mM)

Bioactivity

Target IC50
PKCθ:12 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, Protein kinase C, PKCtheta inhibitor, PKC-theta inhibitor, PKC theta inhibitor, PKC, PKCθ

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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100 mg
$ 820.00
250 mg
$ 1,250.00
1 g
$ 2,590.00
DispatchUsually dispatched within 5-10 working days
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