PKC-theta inhibitor hcl

SKU: orb1301463

Description

This small molecule is a potent and selective inhibitor of protein kinase C theta (PKC-θ), exhibiting an IC50 of 12 nM. It is a valuable research tool for studying T-cell activation and has been utilized in both in vitro and in vivo models of autoimmune and inflammatory diseases.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2253640-49-0
• MW: 490.91
• Purity: 99.71% (May vary between batches)
• Formula: C₂₀H₂₆ClF₃N₆O₃
• SMILES: Cl.NCC1CCC(CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+]([O-])=O)CC1
• Target: PKC
• Solubility: DMSO:55 mg/mL (112.04 mM)

Bioactivity

• Target IC50:
  PKCθ:12 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PKCtheta inhibitor hcl, PKC-theta inhibitor hcl, PKC theta inhibitor hcl, PKCθ

Compound Identifiers

PubChem CID

137935722