Pim-1/2 kinase inhibitor 1

SKU: orb2900264

Description

Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer.

Key Properties

• CAS Number: 6320-51-0
• MW: 235.26
• Purity: >98% (HPLC)
• Formula: C₁₁H₉NO₃S
• SMILES: COc1ccc(C=C2SC(=O)NC2=O)cc1
• Target: Pim
• Solubility: In Vitro: DMSO : 250 mg/mL (1062.65 mM; Ultrasonic (<60°C)

Bioactivity

• In Vitro:
  Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC of 11 μM. Cell Cytotoxicity Assay Cell line: PC3 cells. Concentration: varying concentrations. Incubation time: 48 h. Result: Inhibited PC3 cells with an IC of 11 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Pim