Pim-1/2 kinase inhibitor 1

SKU: orb1685307

Description

Pim-1/2 Kinase Inhibitor 1 is an orally bioavailable small molecule that blocks Pim kinase activity, specifically inhibiting the phosphorylation of substrates like 4E-BP1 and p27 Kip1. It is a valuable research tool for studying oncogenic signaling in cancers such as prostate cancer, with applications in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 6320-51-0
• MW: 235.26
• Purity: 99.89% (May vary between batches)
• Formula: C₁₁H₉NO₃S
• SMILES: COc1ccc(C=C2SC(=O)NC2=O)cc1
• Target: Pim
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (10.63 mM);DMSO:50 mg/mL (212.53 mM)

Bioactivity

• In Vitro:
  Pim-1/2 kinase inhibitor 1 (compound D14) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM after 48 hours of incubation at varying concentrations .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2,4 Thiazolidinedione, 5 p methoxybenzylidene , 2,4Thiazolidinedione, 5pmethoxybenzylidene, Pim1, Pim-1/2 kinase inhibitor 1, Pim2

Compound Identifiers

PubChem CID

233112