Phyllanthin

SKU: orb1297247

Description

Phyllanthin is a hepatoprotective and antigenotoxic small molecule that also acts as a P-glycoprotein (P-gp) inhibitor. It is utilized in research areas including hepatotoxicity, chemoprevention, and multidrug resistance, with applications in both in vitro and in vivo experimental models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 10351-88-9
• MW: 418.52
• Purity: 99.99% (May vary between batches)
• Formula: C₂₄H₃₄O₆
• SMILES: COC[C@@H](Cc1ccc(OC)c(OC)c1)[C@@H](COC)Cc1ccc(OC)c(OC)c1
• Target: NF-κB,TGF-beta/Smad
• Solubility: DMSO:55 mg/mL (131.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.78 mM)

Bioactivity

• In Vitro:
  The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phyllanthin, Phyllanthus, hepatoprotective, Inhibitor, inhibit, lignan, NF-κB, NFkB, NF-kB, NFκB, bioactive, antioxidative, amarus

Compound Identifiers

PubChem CID

358901