Hypophyllanthin

SKU: orb1297335

Description

Hypophyllanthin and phyllanthin are bioactive lignans exhibiting antitumor activity, as demonstrated in studies using the Ehrlich Ascites Carcinoma mouse model. These compounds are utilized in cancer research to investigate their mechanisms of action and therapeutic potential in both in vivo and in vitro experimental settings.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 33676-00-5
• MW: 430.49
• Purity: 98.39% (May vary between batches)
• Formula: C₂₄H₃₀O₇
• SMILES: COC[C@H]1Cc2cc(OC)c3OCOc3c2[C@H]([C@@H]1COC)c1ccc(OC)c(OC)c1
• Target: P-gp|||Potassium Channel|||Calcium Channel
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (7.67 mM);DMSO:100 mg/mL (232.29 mM)

Bioactivity

• In Vitro:
  The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MDR1, Hypophyllanthin, Multidrug resistance protein 1, inhibit, Inhibitor, Cluster of differentiation 243, CD243, CalciumChannel, Calcium Channel, ABCB1, Potassium Channel, PotassiumChannel, P-gp, P-gp (P-glycoprotein), Pgp, P-glycoprotein

Compound Identifiers

PubChem CID

71749431