PF-5274857

SKU: orb1301768

Description

PF-5274857 is a potent and selective hedgehog pathway inhibitor (Smo IC50: 5.8 nM) with demonstrated blood-brain barrier penetration. Its oral bioavailability and metabolic stability support its use in preclinical research for Hh-driven tumors, including medulloblastoma and brain metastases, as shown in in vivo survival studies.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1373615-35-0
• MW: 436.96
• Purity: 98.99% (May vary between batches)
• Formula: C₂₀H₂₅ClN₄O₃S
• SMILES: Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O
• Target: Smo
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.15 mM);DMSO:125 mg/mL (286.07 mM)

Bioactivity

• Target IC50:
  Smo:5.8 nM (IC50)|Smo:Ki: 4.6 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Smoothened, smo, Smo, PF 5274857, PF-5274857, PF-5274857 free base, PF-5274857 freebase, PF5274857, pathway, metastasis, driven, brain

Compound Identifiers

PubChem CID

56956240