PF-5274857 hydrochloride

SKU: orb1694509

Description

PF-5274857 hydrochloride is a potent, selective, and orally bioavailable Smoothened (Smo) antagonist with an IC50 of 5.8 nM, capable of crossing the blood-brain barrier. It is utilized in preclinical research to investigate Hedgehog pathway-driven malignancies, including primary brain tumors and metastatic brain cancers, in both cellular and animal models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1613439-62-5
• MW: 473.42
• Formula: C₂₀H₂₆Cl₂N₄O₃S
• SMILES: Cl.Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O
• Target: Smo,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

90489027