PF-5274857 mseylate (1373615-35-0 free base)

SKU: orb1986875

Description

PF-5274857 is a potent, selective, and orally bioavailable Smoothened (Smo) inhibitor of the Hedgehog pathway. It demonstrates excellent brain penetration and has shown efficacy in preclinical medulloblastoma models, improving survival in vivo, making it a valuable tool for cancer research.

Key Properties

• MW: 533.06
• Formula: C₂₁H₂₉ClN₄O₆S₂
• SMILES: O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.OS(=O)(C)=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168012558