PD-1/PD-L1-IN 6

SKU: orb1688070

Description

PD-1/PD-L1-IN 6 (Compound A13) is a potent small molecule inhibitor of the PD-1/PD-L1 immune checkpoint, exhibiting an IC50 of 132.8 nM. It demonstrates significant immunoregulatory activity in vitro, restoring T-cell function and enhancing interferon-γ secretion in co-culture models without significant cytotoxicity, supporting its use in immuno-oncology research.

Research Area

Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2393983-76-9
• MW: 402.49
• Formula: C₂₅H₂₆N₂O₃
• SMILES: C(=O)(N1C=2C(=C(C=CC2)C3=CC=CC=C3)CC1)C4=CC(OC)=C(CNCCO)C=C4
• Target: Others,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162650815