INCB086550

SKU: orb1693347

Description

INCB086550 (PD-1/PD-L1-IN-8) is a potent small-molecule inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of ≤10 nM. It is a valuable research tool for investigating immune checkpoint blockade in both in vitro cellular assays and in vivo preclinical cancer models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2230911-59-6
• MW: 693.79
• Purity: 98.49% (May vary between batches)
• Formula: C₄₁H₃₉N₇O₄
• SMILES: Cc1c(Nc2nccc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C
• Target: PD-1/PD-L1
• Solubility: DMSO:145 mg/mL (209 mM);H2O:75.6 mg/mL (108.97 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

INCB 086550, INCB086550, INCB-086550, PD-1/PD-L1-IN-8, PD-1/PD-L1, PD1/PDL1, PD-1, PD1, PDL1, PD-L1

Compound Identifiers

PubChem CID

135146787