PD 123319

SKU: orb1301103

Description

PD 123319 ((S)-(+)-PD 123319) is a selective and potent antagonist of the angiotensin II type 2 (AT2) receptor. It is widely used in cardiovascular, renal, and neurological research to delineate AT2 receptor functions in both in vitro assays and in vivo animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 130663-39-7
• MW: 508.61
• Purity: 99.17%
• Formula: C₃₁H₃₂N₄O₃
• SMILES: C(N1C2=C(CN(C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@H](C(O)=O)C2)N=C1)C5=CC(C)=C(N(C)C)C=C5
• Target: RAAS
• Solubility: DMSO:55 mg/mL (108.14 mM);H2O:196.6 mM

Bioactivity

• Target IC50:
  AT2 receptor:34 nM
• In Vivo:
  125I-AII specifically labeled two classes of AII binding sites in bovine adrenal glomerular cell membrane preparations. The first class (DuP-753-sensitive) accounted for approximately 85% of the total AII binding sites and had a high affinity for DuP-753 (IC 50 of 92.9 nM).PD-123319 had no effect on the binding of 125I-AII to this site. The second type of binding site is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 of about 10 μM).
• In Vitro:
  Intravenous administration of PD 123319 to conscious hypertensive rats caused an immediate dose-dependent increase in MAP, and this effect was maintained for approximately 7.4 min with 3 mg/kg of PD 123319.PD 123319 had no effect on the self-regulation of cerebral blood flow.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Angiotensin Receptor, AT2 receptor, (S)-(+)-PD 123319, inhibit, PD 123319, PD123319, PD-123319, Inhibitor

Compound Identifiers

PubChem CID

5311345