PD 123319

SKU: orb1226581

Description

A potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.Heart Failure Discontinued.

Key Properties

• CAS Number: 130663-39-7
• MW: 508.6108
• Purity: >98% (HPLC)
• Formula: C₃₁H₃₂N₄O₃
• SMILES: CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C
• Target: Angiotensin Receptor
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PD123319 | PD-123319 | (S)-(+)-PD 123319

Quick Database Links

Gene Symbol

Angiotensin Receptor