PAT-1251

SKU: orb1708935

Description

PAT-1251 is a LOXL2 inhibitor exhibiting IC50 values of 10 μM (mouse), 0.12 μM (rat), and 0.16 μM (dog). It serves as a research tool for investigating fibrotic diseases in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 2007885-39-2
• MW: 399.34
• Purity: 99.78% (May vary between batches)
• Formula: C₁₈H₁₇F₄N₃O₃
• SMILES: NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F
• Target: Monoamine Oxidase
• Solubility: H2O:100 mg/mL (250.41 mM);DMSO:100 mg/mL (250.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  LOXL2 (human):0.71 μM|LOXL2 (mouse):0.10 μM|LOXL2 (rat):0.12 μM|LOXL3 (human):1.17 μM|LOXL2 (dog):0.16 μM
• In Vitro:
  PAT-1251 inhibits hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM. PAT-1251 shows highly selective for LOXL2 over other amine oxidases, such as SSAO, DAO, MAO-A, and MAO-B with <10% inhibition at 10 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2098884-52-5, Dog LOXL2, hLOXL2, hLOXL3, Lenumlostat, Monoamine Oxidase, MonoamineOxidase, Mouse LOXL2, PAT 1251, PAT-1251, PAT1251, LOXL2, Rat LOXL2

Compound Identifiers

PubChem CID

122536283