Lenumlostat

SKU: orb1739567

Description

Lenumlostat

Research Area

Neuroscience

Key Properties

• CAS Number: 2098884-52-5
• MW: 399.34
• Purity: 99.88% (May vary between batches)
• Formula: C₁₈H₁₇F₄N₃O₃
• SMILES: O(C=1N=C(C(F)(F)F)C=C(CN)C1)C2=CC(C(=O)N3C[C@@H](F)[C@H](O)C3)=CC=C2
• Target: Monoamine Oxidase
• Solubility: DMSO:45 mg/mL (112.69 mM);H2O:80 mg/mL (200.33 mM)

Bioactivity

• Target IC50:
  LOXL3 (human):1.17 μM|LOXL2:0.10 μM (Mouse)|LOXL2:0.12 μM (Rat)|LOXL2:0.16 μM (Dog)|LOXL2 (human):0.71 μM
• In Vitro:
  Lenumlostat(PAT-1251)is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 μM and 1.17 μM for hLOXL2 and hLOXL3, respectively. It also potently inhibits LOXL2 in mouse, rat, and dog, with IC50s of 0.10 μM, 0.12 μM, and 0.16 μM, respectively. Lenumlostat(PAT-1251) exhibits high selectivity for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO). Additionally, it shows selectivity against the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with less than 10% inhibition at 10 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MonoamineOxidase, Monoamine Oxidase, PAT-1251, LOXL2, GB2064, 2007885-39-2

Compound Identifiers

PubChem CID

122536283