PAK1 (N2) Antibody, Rabbit Polyclonal

• Catalog Number: orb67264
• Category: Antibodies
• Description: Rabbit polyclonal to PAK1.p21-activated kinase 1 (PAK1) belongs to the protein kinase superfamily, STE Ser/Thr protein kinasefamily and STE20 subfamily. PAK1 can be activated by CDC42 and RAC1, and is likely the GTPaseeffector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK1 is involved in thedissolution of stress fibers and reorganization of focal complexes, as well as in the regulation ofmicrotubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complexwith MUSK which is important for MUSK-dependent regulation of AChR clustering during theformation of the neuromuscular junction (NMJ). The activity of PAK1 is inhibited in cells undergoingapoptosis, potentially due to binding of CDC2L1 and CDC2L2.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human, Mouse
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: N-terminal region of human PAK1
• UniProt ID: Q13153
• MW: 61
• Tested applications: WB
• Dilution range: WB:1:500-1:2000
• Storage: -20°C
• Alternative names: anti-PAK1 antibody,anti-Serine antibody,anti-threo
• Note: For research use only

Western blot analysis of total cell extracts from human Hela(Lane1)