PAK1 (N2) Antibody, Rabbit Polyclonal

SKU: orb67264

Description

Rabbit polyclonal to PAK1.p21-activated kinase 1 (PAK1) belongs to the protein kinase superfamily, STE Ser/Thr protein kinasefamily and STE20 subfamily. PAK1 can be activated by CDC42 and RAC1, and is likely the GTPaseeffector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK1 is involved in thedissolution of stress fibers and reorganization of focal complexes, as well as in the regulation ofmicrotubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complexwith MUSK which is important for MUSK-dependent regulation of AChR clustering during theformation of the neuromuscular junction (NMJ). The activity of PAK1 is inhibited in cells undergoingapoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Research Area

Apoptotic, Cancer, Epigenetics, Neuroscience, Signaling Pathways

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:2000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human PAK1
• Molecular Weight: 61
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-PAK1 antibody,anti-Serine antibody,anti-threonineprotein kinase PAK 1 antibody,anti-AlphaPAK antibody,anti-p21activated kinase 1 antibody,anti-PAK1 antibody,anti-p65PAK Source and antibody

Western blot analysis of total cell extracts from human Hela(Lane1),mouse thymus(Lane2) and mouse brain(Lane3) using PAK1 antibody

Quick Database Links

UniProt

Q13153