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p38α inhibitor 9

SKU: orb3028410

Description

p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2133007-20-0
MW457.496
FormulaC27H24FN3O3
SMILESO=C(NC)C1=CC=C2C(=C1)C(=O)C3=CC=C(C=C3CC2)NC4=CC=C(F)C(=C4)NC(=O)C5CC5
TargetWee1,MAPK,CDK,p38 MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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