PF-719

SKU: orb1473141

Description

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.

Key Properties

• CAS Number: 1404454-02-9
• MW: 521.41
• Purity: >98%
• Formula: C₂₂H₂₉Cl₂F₃N₆O
• SMILES: O=C(NC1CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4[C@H](N(C)C)CCC4)=N3)C=C2

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only