AMG-47a

SKU: orb1300050

Description

AMG-47a is a potent small molecule inhibitor of lymphocyte-specific protein tyrosine kinase (Lck), suppressing T-cell proliferation. It also acts as a selective degrader of the KRASG12V oncoprotein, as demonstrated in cellular studies, making it a valuable tool for oncology and immunology research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 882663-88-9
• MW: 535.56
• Purity: 98.06% (May vary between batches)
• Formula: C₂₉H₂₈F₃N₅O₂
• SMILES: Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
• Target: Src,VEGFR,JAK,Ras,p38 MAPK,Kras
• Solubility: DMSO:34 mg/mL (63.48 mM)

Bioactivity

• Target IC50:
  Lck:0.2 nM (IC50)|p38α:3 nM (IC50)|VEGF2:1 nM (IC50)|JAK3:72 nM (IC50)|MLR:30 nM (IC50)|IL-2:21 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Janus kinase, JAK, immune, kinases, Inhibitor, inhibit, family, Lck, AMG 47a, AMG47a, AMG-47a, cell, cytoplamic, p38 MAPK, p38MAPK, receptor, signal, specific, Src, responses, VEGFR, Vascular endothelial growth factor receptor, transduction, tyrosine

Compound Identifiers

PubChem CID

16086114