Oxyphenisatin acetate

SKU: orb1299931

Description

Oxyphenisatin acetate is a small molecule compound that suppresses proliferation in breast cancer cell lines including MCF7, T47D, HS578T, and MDA-MB-468. It serves as a useful research tool for in vitro studies investigating oncology pathways and potential therapeutic mechanisms.

Research Area

Cell Biology

Key Properties

• CAS Number: 115-33-3
• MW: 401.41
• Purity: 99.35% (May vary between batches)
• Formula: C₂₄H₁₉NO₅
• SMILES: CC(=O)Oc1ccc(cc1)C1(C(=O)Nc2ccccc12)c1ccc(OC(C)=O)cc1
• Target: Autophagy
• Solubility: DMSO:150 mg/mL (373.68 mM)

Bioactivity

• In Vitro:
  In the estrogen receptor (ER) positive MCF7 and T47D cells, OXY induced TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Lastly, in an MCF7 xenograft model, OXY delivered intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1. OXY induces a multifaceted cell starvation response, which ultimately induces programmed cell death.
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• Cell Research:
  Total RNA was isolated from MCF7 cells treated with 10 μmol/L OXY for 24 h and the microarray procedure performed as described previously using the GeneChip Human U133 plus 2.0 array . Pairwise analysis was performed on control versus treated arrays using a fivefold change cutoff, <0.01 adjusted P-value, GC-RMA normalization with Benjamini–Hochberg false discovery estimation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, Oxyphenisatin, Oxyphenisatin acetate, Oxyphenisatin Acetate, Inhibitor

Compound Identifiers

PubChem CID

8269