Oxyphenisatin acetate

SKU: orb1220476

Description

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.

Key Properties

• CAS Number: 115-33-3
• MW: 401.41
• Purity: >98% (HPLC)
• Formula: C₂₄H₁₉NO₅
• SMILES: CC(=O)Oc1ccc(cc1)C1(C(=O)Nc2ccccc12)c1ccc(OC(C)=O)cc1
• Target: Autophagy
• Solubility: DMSO:150 mg/mL (373.68 mM)

Bioactivity

• In Vivo:
  Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.
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• In Vitro:
  Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy