Oxyphenisatine

SKU: orb2900588

Description

Oxyphenisatine (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is the pro-agent of oxyphenisatin with anticancer activity.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 125-13-3
• MW: 317.34
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₅NO₃
• SMILES: Oc1ccc(cc1)C1(C(=O)Nc2ccccc12)c1ccc(O)cc1
• Solubility: In Vitro: DMSO : 250 mg/mL (787.80 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52.
  Read more...
• In Vitro:
  Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC50 = 0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only