OPHIOPOGONIN D

SKU: orb1301570

Description

Ophiopogonin D is a natural steroidal glycoside that acts as a CYP2J3 inducer. It has been shown in vitro to effectively suppress Angiotensin II-induced NF-κB nuclear translocation, making it a useful research tool for studying cardiovascular and inflammatory pathways.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 945619-74-9
• MW: 855.02
• Purity: ≥95% (May vary between batches)
• Formula: C₄₄H₇₀O₁₆
• SMILES: C[C@@]12[C@@]3([C@](C[C@]1([C@]4([C@](CC2)([C@@]5(C)[C@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@H](O)CO8)[C@@H](O)[C@@H](C)O6)C[C@H](O)CC5=CC4)[H])[H])[H])(O[C@@]9([C@H]3C)CC[C@@H](C)CO9)[H])[H]
• Target: RAAS|||NF-κB|||Calcium Channel|||PPAR
• Solubility: DMSO:30 mg/mL (35.09 mM);10% DMSO+90% Corn Oil:2 mg/mL (2.34 mM)

Bioactivity

• In Vitro:
  OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs. Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level. Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate. Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D. Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, Calcium Channel, Ca2+ channels, Ca channels, angiotensin II receptor, Inhibitor, inhibit, NF-κB, NFκB, NF-kB, NFkB, Nuclear factor-kappaB, Nuclear factor-κB, OPHIOPOGONIN D, Peroxisome proliferator-activated receptors, PPAR

Compound Identifiers

PubChem CID

46173859