Ophiopogonin D'

SKU: orb1297572

Description

Ophiopogonin D'

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 65604-80-0
• MW: 855.02
• Purity: 99.13% (May vary between batches)
• Formula: C₄₄H₇₀O₁₆
• SMILES: [H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@]1([H])O[C@H](CO)[C@@H](O)[C@H](O[C@]2([H])OC[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
• Target: UGT|||Sirtuin
• Solubility: DMSO:8.56 mg/mL (10.01 mM)

Bioactivity

• In Vitro:
  In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, Ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ophiopogonin D', inhibit, Inhibitor, Sirtuin, SIRT1, UGT1A6

Compound Identifiers

PubChem CID

10033524