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NVP-BHG712

SKU: orb1223579

Description

NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.

Images & Validation

Key Properties

CAS Number940310-85-0
MW503.489
Purity>98% (HPLC)
FormulaC26H20F3N7O
SMILESO=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(NC3=C4C(N(C)N=C4)=NC(C5=CC=CN=C5)=N3)=C2
TargetEphrin Receptor
Solubility10 mM in DMSO

Bioactivity

In Vivo
Animal model: Mice arrying chambers. Dosage: 3, 10 and 30 mg/kg. Administration: p.o. daily for 4 days. Result: Significantly inhibited VEGF stimulated tissue formation and vascularization at doses of daily 3 mg/kg. Administration of 10 mg/kg/kg p.o. was sufficient to reverse VEGF enhanced tissue formation and vessel growth.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NVP BHG712 | NVP BHG-712 | NVP BHG 712 | BHG-712 | BHG712

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Protocol Information

NVP-BHG712 (orb1223579)

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200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 320.00
50 mg
$ 560.00
100 mg
$ 820.00