NVP-BHG712 isomer

SKU: orb1307008

Description

The NVP-BHG712 isomer is a selective inhibitor that binds with conserved affinity to both EPHA2 and EPHB4 receptor tyrosine kinases. It is a valuable research tool for studying Eph receptor signaling in cancer angiogenesis and tumor progression, with utility in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2245892-85-5
• MW: 503.48
• Purity: 99.65%
• Formula: C₂₆H₂₀F₃N₇O
• SMILES: Cc1ccc(cc1Nc1nc(nc2nn(C)cc12)-c1cccnc1)C(=O)Nc1cccc(c1)C(F)(F)F
• Target: Ephrin Receptor
• Solubility: DMSO:50 mg/mL (99.31 mM);H2O:insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.97 mM)

Bioactivity

• Target IC50:
  EphA2:163 nM
• In Vitro:
  NVP-BHG712 isomer exhibits IC50 of 163 nM and 1660 nM for EPHA2 and EPHA4, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Ephrin Receptor, EphrinReceptor, EPHA2, EphA2, inhibit, NVP BHG712 isomer, NVPBHG712 isomer, NVP-BHG712 isomer, NVP-BHG-712 isomer

Compound Identifiers

PubChem CID

117602383