NVP-ADW742

SKU: orb1301092

Description

NVP-ADW742 (ADW) is a potent and selective small molecule inhibitor of IGF-1R (IC50 = 0.17 μM), exhibiting over 16-fold selectivity versus the closely related InsR. It has been utilized in research to study IGF-1R signaling in cancer models, demonstrating antitumor activity in vitro and in vivo studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 475488-23-4
• MW: 453.58
• Purity: 98.70%
• Formula: C₂₈H₃₁N₅O
• SMILES: Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)C1CC(CN2CCCC2)C1
• Target: Apoptosis,IGF-1R
• Solubility: DMSO:10 mg/mL (22.05 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:1 mg/mL (2.2 mM);Ethanol:3 mg/mL (6.61 mM)

Bioactivity

• Target IC50:
  IGF-1R:0.17 μM

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

proapoptotic, solid, ADW, ADW 742, ADW742, ADW-742, Apoptosis, InsR, Insulin Receptor, IGF-1R, IGF1R, hematologic, multiple, myeloma, NVP ADW742, NVP-ADW 742, NVPADW742, NVP-ADW742, NVP-ADW-742, pleiotropic

Compound Identifiers

PubChem CID

9825149