cis-NVP-ADW742

SKU: orb2944239

Description

NVP-ADW742 is a potent and selective small molecule inhibitor of IGF-1R, exhibiting an IC50 of 0.17 μM and over 16-fold selectivity versus InsR. It shows minimal activity against a panel of other kinases including HER2 and VEGFR-2. This inhibitor is used in research to study IGF-1R signaling in cancer models both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 475489-15-7
• MW: 453.59
• Formula: C₂₈H₃₁N₅O
• SMILES: NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCCC4)C=C2C5=CC(OCC6=CC=CC=C6)=CC=C5)=NC=N1
• Target: IGF-1R

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IGF1R, IGF-1R, cisNVPADW742

Compound Identifiers

PubChem CID

9825149